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BS - Messiah College
PhD - Pennsylvania State University, College of Medicine
Postdoctoral Fellowship - Harvard Medical School/Massachusetts General Hospital
Visiting Research Associate - University of Pittsburgh
Stem Cell and Regenerative Medicine, Developmental Biology, Kidney
BIOL 111 Principles of Biology
BIOL 203 Genetics and Development
BIOC 481 Stem Cells and Regenerative Medicine
I am interested in understanding kidney regeneration and kidney development using zebrafish as a vertebrate model system. Kidney disease is a major health problem worldwide due to increasing rates of diabetes and hypertension, and current treatments (such as dialysis and kidney transplant) are not meeting the demand of patients. As such, there is an urgent need for an alternative stem cell/regenerative therapy for treating kidney disease. To this end, I have recently identified for the first time stem cells that are capable of regenerating new kidney tissue in adult zebrafish (Diep et al., Nature, 2011). Projects in my lab focus on how these stem cells are regulated during regeneration and determining their role in development of the adult kidney. Understanding the mechanism that controls these stem cells in zebrafish will provide a first step towards developing a novel stem cell/regenerative therapy for treating kidney disease.
Pilauri V, Bewley M, Diep
C, and Hopper J (2005). Gal80 dimerization and the yeast GAL gene
switch. Genetics 169(4):1903-14.
Peng G, Bewley M, Pilauri V, Ropson I, and Hopper JE (2006). Intragenic
suppression of Gal3C interaction with Gal80 in the Saccharomyces cerevisiae GAL
gene switch. Genetics 172(1):77-87.
Tao X, Pilauri V, Losiewicz M, Blank TE, and Hopper JE (2008). Genetic evidence
for sites of interaction between the Gal3 and Gal80 proteins of the
Saccharomyces cerevisiae GAL gene switch. Genetics 178(2):725-36.
Swanhart LM, Cosentino CC, Diep CQ, Davidson AJ, de Caestecker M, and Hukriede NA
(2011). Zebrafish kidney development: Basic science to translational research.
Birth Defects Research (Part C: Embryology Today: Reviews) 93(2):141-156.
Cover art designed by Cuong Diep
and Davidson AJ (2011). Transplantation of cells directly into the kidney of
adult zebrafish. Journal of Visualized Experiments 51 pii: 2725.(http://www.jove.com/details.php?id=2725)
Ma D, Deo RC, Holm TM, Naylor RW, Arora N, Wingert RA, Bollig F, Djordjevic G,
Lichman B, Zhu H, Ikenaga T, Ono F, Englert C, Cowan CA, Hukriede NA, Handin
RI, and Davidson AJ (2011). Identification of adult nephron progenitors capable
of kidney regeneration in zebrafish. Nature 470(7332):95-100. [Reviewed in Cell
Stem Cell 8(3):247-249]
Eichelberger SL and Diep
CQ (2014). Analysis of protein-protein interaction in zebrafish kidney
stem cells. Keystone Journal of Undergraduate Research 2(1): 9-14.
Peng Z, Ukah TK, Kelly PM, Daigle RV, and Davidson AJ (2015). Development of
the zebrafish mesonephros. genesis 53(3-4):257-269.
Cover art designed by Cuong Diep
Denio EK, Kelly PM, and Diep
CQ (2015). Protein-protein interaction analysis reveals a novel
function of the lhx1 transcription factor in zebrafish. BIOS 86(4) December
(2015). In press.
Keshari V, Adeeb DB, Simmons AE, Simmons TW, and Diep CQ. Zebrafish as a model to
assess the teratogenic potential of nitrite. Journal of Visualized Experiments.