A laboratory section of Principles of Cell and Molecular Biology and Organic Chemistry participated in undergraduate research in spring 2016. Students from each section were paired with one another and asked to plan experiments that would probe potential small molecules to effect stem cell regeneration.
Coupling of coursework will link chemical synthesis and small molecule characterization with genomics to better understand molecular and cellular processes in fields such as regenerative medicine and cancer biology.
Each organic subgroup planned the synthesis of primary, secondary, and tertiary alcohols using the sodium borohydride and Grignard reactions. All synthetic products were analyzed for yield and purity using the spectroscopic techniques of NMR, GC/MS and IR. Members of the biology subgroups carried out an investigation on the effects of each alcohol in the small molecule library on aspects of stem-cell-based tissue regeneration in planarian flatworms.
The section group pairs met often outside of their laboratory periods to elucidate and discuss their findings. Members of each subgroup have produced a poster detailing their results which they will present. Intra- and interdisciplinary group member interactions were enhanced with teamwork modules completed at the start of the spring semester.
The poster session detailing the outcomes of the research will be held on Wednesday, April 20, from 6:00–7:00 p.m. in the hallway of the first floor of Weyandt Hall. All are welcome to stop by!
The integrated, interdisciplinary laboratory periods were designed by the research groups of Justin Fair and Robert Major. Theresa Ruffner designed, taught, and evaluated the teamwork learning modules. Anne Kondo was essential with the logistics and evaluation of the experiments.
Maggie Progin Maggie BlaetzPriya SoundararajanStacey NicodemusAngie JohnsonGerneleh PayeKayla GabanyDenali DavisBrandon WellerOlivia LeitzelMarkia GordonKalyn LundbergAnthony LewisNicole VenutiBryana MitchellDerek RocksTashi BharathanHannah PharSam PavolkoAlexiss PriceAlex LaBueAnissa DelfonsoNicole KinjerskiTierra Williams
Vanessa BouchBrooke BrociousBrandon CoxDeanne CudaJennifer DoddKayla FerrellCarrie GleasonChasity HankinsonMatthew JanoskoAllison KickAlayna MellottJohn MillerCristina NievesMacKenzie RaceLeah TaylorMichelle WilliamsMichael Zacur
Department of Chemistry