Science Inspires Series: “Bacterial Resistance and Why We Should Care”

Posted on 3/8/2016 12:06:16 PM

Biochemist Herman O. Sintim will present on bacterial resistanceThe College of Natural Sciences and Mathematics and the IUP Sigma Xi Chapter proudly present Dr. Herman Sintim of Purdue University as the guest speaker of the Spring 2016 Science Inspires Series. A public reception will be held in the Eberly Hall atrium following the talk.

Professor Sintim will present “Bacterial Resistance and Why We Should Care: How Cyclic Dinucleotide Bacteria Could Solve the Antibiotic Resistance Problem” on March 17 at 4:30 p.m. in the Eberly Auditorium. An abstract follows:

According to the US Centers for Disease Control and Prevention (CDC), antibiotic-resistant pathogens make over 2 million Americans sick every year and over 23,000 deaths per year could be attributed to these bugs.

Worryingly, there are a few pathogens, the so-called super-bugs, that are resistant to a plethora of antibiotics. In the last decade most of the antibacterial agents that were approved by the FDA met the same antibiotic resistance fate, probably because these agents were mere derivatives of existing drugs, for which resistant bacterial strains already existed. The current antibiotic resistance crisis and the projection that this problem will worsen calls for immediate action to identify new tactics to tackle multidrug-resistant bacteria.

We are currently witnessing a cyclic dinucleotide revolution that promises to usher in a new class of antibacterial agents. In this talk, I will discuss some of our efforts to develop novel antibacterial agents that target bacterial communication networks, including cyclic dinucleotide signaling.

Dr. Sintim obtained his BS in Medicinal Chemistry from the University College London and D.Phil. in Organic Chemistry from Oxford University, under the guidance of Professor David Hodgson. He then performed postdoctoral research in the chemistry of natural products at the University of Oxford in the laboratory of Professor Timothy Donohoe and a second postdoctoral research in Chemical Biology investigating the rules that govern DNA replication at Stanford University in the laboratory of Professor Eric Kool. In 2006, Sintim began his independent research at the University of Maryland as an assistant professor of chemical biology and was promoted to associate professor in 2012. In 2015, he was promoted to full professor and soon afterwards accepted an offer to move his laboratory to Purdue University.