A laboratory section of Principles of Cell and Molecular Biology and Organic
Chemistry participated in undergraduate research in spring 2015. Students
from each section were paired with one another and asked to plan experiments
that would probe potential small molecules to effect stem cell regeneration.
Coupling of coursework will link chemical synthesis and small molecule characterization with genomics to better understand molecular and cellular processes in fields such as
regenerative medicine and cancer biology.
Each organic subgroup planned the synthesis of primary, secondary, and tertiary
alcohols using the sodium borohydride and Grignard reactions. All synthetic
products were analyzed for yield and purity using the spectroscopic techniques
of NMR, GC/MS and IR. Members of the biology subgroups carried out an
investigation on the effects of each alcohol in the small molecule library on
aspects of stem-cell-based tissue regeneration in planarian flatworms.
The section group pairs met often outside of their laboratory periods to
elucidate and discuss their findings. Members of each subgroup have produced a
poster detailing their results which they will present.
The poster session detailing the outcomes of the research will be held on Wednesday, April 22, from 3:30–4:30 p.m. in the hallway of the first floor of Weyandt Hall. All are welcome to stop by!
The integrated, interdisciplinary laboratory periods were designed by the research groups of Justin Fair and Robert Major. Anne Kondo was essential with the logistics and evaluation of the experiments.
Thomas ArmstrongKristen BaumgartnerAlexandra BechtelHanna BeightleyCarlyn BrechtNatalie CignettiAshlyn DearmittLewis DominguezKimberly GhormKristina KureljaMegan MaleyMitchell MarkunasAlexander MonganKelly ParsonsKellsey PieplesSamantha RichardBrooke SaxingerMadysen SchweersBrianna ShowmanPaul SimpsonSummer SlupeMaddie TregoMadison UllmanAlexis VollmerAlyssa Zabicki
Edgar CeballosKelsey ClaypoolJoseph CristelloAshlyn DearmittLuke GalbraithSara GustafsonSamuel HorwathKristen HowettStephanie LazorcikChristina MaziarzPaul SingermanNicholle WilliamsStephanie WolfeBlake Woodyard