Dr. Avijita Jain

Professor

Office: 253 Kopchick Hall
Phone: 724-357-2368
Email: Avijita.Jain@iup.edu

Education

BS, Barkatullah University
MS, Tennessee Technological University
PhD, Virginia Tech
Postdoctoral Fellowship, Pacific Northwest National Laboratory

Field

Bioinorganic Chemistry
Organometallic Chemistry
Biochemistry

Courses

BIOC 481: Drug Design and Bioinorganic Chemistry
CHEM 101/102: College Chemistry I/II
CHEM 255: Biochemistry and Nutrition

Research Interests

My research interests revolve around development of electroactive and photoactive transition metal complexes with applications in photodynamic therapy and H₂ production. The three research projects that I am working on are:

• Design and development of tumor selective, peptide coupled organometallic photodynamic therapy (PDT) agents
• Design and development of water oxidation electrocatalysts
• Design and development of novel fluorescent sensors for monitoring protein phosphorylation

Select Publications

1. Galan, B. R.; Reback, M. L.; Jain, A.; Apple, A. M.; Shaw W. J. Electrocatalytic Oxidation of Formate with Nickel Diphosphine Dipeptide Complexes: Effect of Ligands Modified with Amino Acids. Eur.J. Inorg. Chem. 2013 , 30, 5366-5371.
2. Buchko, G. W.; Jain, A .; Reback, M. L.; Shaw W. J. Structural characterization of the model amphipathic peptide Ac-LKKLLKLLKKLLKL-NH₂ in aqueous solution and with 2,2,2-trifluoroethanol and 1,1,1,3,3,3-hexafluoroisopropanol. Can. J. Chem. 2013 , 91, 406-413.
3. Reback, M. L.; Pangovska, B. G.; Ho, M. H.; Jain, A .; Squier, T. C; Raugei, S.; Roberts, J. A. S; Shaw, W. J. The role of a dipeptide outer-coordination sphere on H₂-production catalysts: influence on catalytic rates and electron transfer. Inorg. Chem. 2013, 19(6), 1928-1941.
4. Jain, A .; Buchko, G. W.; Reback, M. L.; O'Hagan M.; Pangovska, B. G.; Linehan, J. C.; Shaw W. J. Active hydrogenation catalyst with a structured, peptide-based outer-coordination sphere. ACS Catal. 2012 , 2, 2114-2118.
5. Lense, S.; Ho, M. H.; Chen, S.; Jain, A.; Raugei, S.; Linehan J. C.; Roberts J. A. S.; Appel, A. M.; Shaw W. J. Incorporating amino acid esters into catalysts for hydrogen oxidation: steric and electronic effects and the role of water as a base. Organometallics 2012 , 31, 6719-6731.
6. Jain, A.; Reback, M. L.; Lindstrom, M. L.; Thorgeson, C. E.; Helm, M. L.; Appel A. M.; Shaw, W. Investigating the role of the outer-coordination Sphere in [Ni(P^Ph₂N^Ph-R₂)₂]²⁺ hydrogenase mimics. Inorg. Chem. 2012, 51(12), 6592-6602.
7. Jain, A ; Helm, M. L.; Linehan, J. C.; Dubois D. L.; Shaw W. J. Biologically derived phosphino platinum complexes. Inorg. Chem. Commun. 2012 , 22, 65-67.
8. Jain, A. ; Lense, S.; Linehan J. C.; Raugei, S.; Cho, H.; DuBois D. L.; Shaw, W. J. Incorporating peptides in the outer-coordination sphere of bioinspired electrocatalysts for hydrogen production. Inorg. Chem. 2011, 50(9), 4073-4085.
9. Jain, A .; Wang, J. Macshaw, E.; Winkel B. S. J.; Brewer K. J. Multifunctional DNA interactions of Ru-Pt mixed metal supramolecular complexes with substituted terpyridine ligands. Inorg. Chem. 2009 , 48(19), 9077-9084.
10. Prussin A. J.; Zhao S.; JainA .; Winkel B. S. J.; Brewer K. J DNA interaction studies of tridentate bridged Ru(II)-Pt(II) mixed-metal supramolecules. J. Inorg. Biochem. 2009, 103(3), 427- 431.
11. Arachchige, S. M.; Brown, J. R.; Chang, E.; Jain, A .; Zigler, D. F.; Rangan, K.; Brewer, K. J. Design considerations for a system for photocatalytic hydrogen production from water employing mixed-metal photochemical molecular devices for photoinitiated electron collection. Inorg. Chem. 2008 , 48(5), 1989-2000.
12. Jain, A.; Slebodnick, C.; Winkel, B. S. J.; Brewer, K. J. Enhanced DNA photocleavage properties of Ru(II) terpyridine complexes upon incorporation of methylphenyl substituted terpyridine and/or the polyazine bridging ligand dpp (2,3-bis(2-pyridyl)pyrazine). J.Inorg. Biochem. 2008 , 102(10), 1854-1861.
13. Prussin, A. J., II; Zigler, D. F.; Jain, A .; Brown J. R.; Winkel, B. S. J.; Brewer, K. J. Photochemical methods to assay DNA photocleavage using supercoiled pUC18 DNA and LED or xenon arc lamp excitation. J. Inorg. Biochem . 2008 , 102(4), 731-739.
14. Jain,A .; Winkel, B. S. J.; Brewer, K. J. In vivo inhibition of E-coli growth by a Ru(II)/Pt(II) supramolecule [(tpy)RuCl(dpp)PtCl₂](PF₆) J. Inorg. Biochem . 2007 , 101(10), 1525-1528.