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Dr. Christina Ruby

Dr. Christina Ruby Kent Contact Information
Office Hours

Education

B.A. Psychology – Miami University
Ph.D. Physiology – Kent State University
Postdoctoral Fellowship, Neurobiology of Alcoholism and Addiction – Mayo Clinic College of Medicine

Field

Behavioral and Molecular Neuroscience

Interests

Neuropsychiatric disorders, including addiction, are public enemy number one in North America, contributing twice the disease burden of even cardiovascular disease or cancer and costing the USA nearly 600 billion dollars per year. Current treatments are extremely limited, with relapse to alcohol and/or drugs common in individuals even after years of abstinence. Thus, there is an urgent need to develop novel, effective therapeutic strategies for alcohol and drug use disorders.

A large body of evidence suggests that circadian rhythm and sleep disruption may play a central role in drug abuse and relapse. Research in my lab aims to characterize this role in rodent models using a combination of cutting-edge techniques in the areas of molecular biology, neurochemistry, pharmacology, and behavioral neuroscience. My ultimate goals are to elucidate the mechanisms involved in the pathophysiology of addiction and related psychiatric disorders and to translate my research into clinical practice.

Current Projects

  1. Disruption of mammalian circadian timing by alcohol and stimulant
  2. Brain region-specific roles of clock genes in addictive behavior
  3. The role of reward circuitry in circadian timing and sleep
  4. The role of the circadian system in mood disorders

Student Training

I feel strongly that students get the best scientific training when they can participate in innovative research that answers new questions. Students in my lab will learn to apply methodology ranging from the gene to the behavioral levels, including real-time PCR, in vivo microdialysis, confocal microscopy, and a wide variety of neurobehavioral analyses. My goal is that each student in my lab will have the opportunity to publish their research and/or present it professionally.

Publications

Ruby CL, Adams CA, Hinton, DJ, Abulseoud OA, O’Connor KM, Walker DL, Choi DS (2013) Circadian basis for the regulation of alcohol intake and hyperactivity by striatal adenosine. Submitted.

Ruby CL, O’Connor KM, Ayers-Ringler J, Choi DS (2013) Adenosine and glutamate in neuroglial interaction: Implications for circadian disorders and alcoholism. Glutamate and ATP at the Interface of Metabolism and Signaling in the Brain. Vladimir Parupura (Ed.), Springer, New York, USA. In revision.

Abulseoud OA, Camsari UM, Ruby CL, Kasasbeh A, Ahmed AT, Choi S, Choi DS (2013) Attenuation of ethanol withdrawal by ceftriaxone-induced upregulation of glutamate transporter EAAT2. Neuropsychopharmacology, in revision.

Nam HW, Hinton DJ, Kang NY, Kim TH, Lee, MR, Oliveros, A, Adams, CA, Ruby CL, Choi DS (2013) Adenosine transporter ENT1 regulates the acquisition of goal-directed behavior and ethanol drinking through A2A receptors in the dorsomedial striatum. J Neurosci 33: 4329–4338.

Lee MR, Ruby CL, Hinton DJ, Choi S, Adams CA, Kang NY, Choi DS (2013) Striatal adenosine signaling regulates EAAT2 and astrocytic AQP4 expression and alcohol drinking in mice. Neuropsychopharmacology 38: 437-45.

Ruby CL, Adams CA, Mrazek DA, Choi DS (2011) Adenosine signaling in anxiety. Anxiety Disorders. Vladimir Kalinin (Ed.), InTech, Rijeka, Croatia.

Ruby CL, Walker DL, An J, Kim J, Choi DS (2011) Sex-specific regulation of depression, anxiety-like behaviors and alcohol drinking in mice lacking ENT1. J Addict Res Ther S4: 1-6.

Brager AJ, Ruby CL, Prosser RA, Glass JD (2011) Acute ethanol disrupts photic and serotonergic circadian clock phase-resetting in the mouse. AlcoholClin Exp Res 35: 1467-1474.

Ruby CL, Adams C, Knights E, Nam HW, Choi DS (2010) An essential role for adenosine-mediated glutamate signaling in alcohol use disorders. CurrDrug Abuse Rev 3: 163-174.

Hammer SB, Ruby CL, Brager AJ, Prosser RA, Glass JD (2010) Environmental modulation of alcohol intake in hamsters: effects of wheel running and constant light exposure. Alcohol Clin Exp Res 34: 1-8.

Brager AJ, Ruby CL, Prosser RA, Glass JD (2010) Chronic ethanol disrupts circadian photic entrainment and daily locomotor activity in the mouse. AlcoholClin Exp Res 34: 1266-1273.

Ruby CL, Brager AJ, DePaul MA, Prosser RA, Glass JD (2009) Chronic ethanol attenuates circadian photic phase-resetting and alters nocturnal activity patterns in the hamster. Am J Physiol Regul Integr Comp Physiol 297: R729-R737.

Ruby CL, Prosser RA, DePaul MA, Roberts RJ, Glass JD (2009) Acute ethanol impairs photic and nonphotic circadian phase-resetting in the Syrian hamster. Am J Physiol Regul Integr Comp Physiol 296: R411-R418.

  • Biology Department
  • Weyandt Hall, Room 114
    975 Oakland Avenue
    Indiana, PA 15705-1081
  • Phone: 724-357-2352
  • Fax: 724-357-5524
  • Office Hours
  • Monday through Friday
  • 7:30 a.m.–12:00 p.m.
  • 1:00 p.m.–4:00 p.m.