Skip to Content - Skip to Navigation

How Lithium Disrupts Circadian Rhythms for Cadmium Toxicity in Paramecium Tetraurelia

By Kristin Juhasz

Paramecium behaviors can illustrate mechanisms that influence biological rhythms and cellular processes. Using Paramecium tetraurelia wild type strain 51s and a cadmium chronotoxicity assay, we have shown that exposure to lithium alters the circadian rhythm of Paramecium. Lithium disrupts circadian clocks via an unknown molecular mechanism. Since lithium-based medications are the drug of choice for bipolar disorder and other human psychiatric illnesses, observing how lithium disrupts circadian responses has potential clinical significance.

  • Undergraduate Scholars Forum
  • Stright Hall, Room 129
    210 South Tenth Street
    Indiana, PA 15705
  • Phone: 724-357-2244
  • Fax: 724-357-2715
  • Office Hours
  • Monday through Friday
  • 8:00 a.m. – 12:00 p.m.
  • 1:00 p.m. – 4:30 p.m.