Office: Weyandt 212C
E-mail: Daniel.Croft@iup.edu
Telephone: 724-357-2278
Office Hours
Education
The University of North Carolina at Greensboro - Greensboro, NC
Master of Science - Biology, August 2004
Thesis Title: “Characterization of the Actin-Binding and Cellular Localization Activities of the Coiled-Coil Domain of MHCKA from Dictyostelium discoideum.”
The University of North Carolina at Greensboro - Greensboro, NC
Bachelor of Science - Biology, May 2003
Allegany College of Maryland - Cumberland, MD
Associate of Applied Science - Medical Laboratory Technology, May 1998
Field
Molecular Biology
Cardiovascular Disease and Breast Cancer research
Interests
My cardiovascular research focuses on the molecular changes over time of individuals subjected to a lifestyle intervention that includes nutrition, stress management, mind/body health, and exercise. The overall goal is the identification of potential biomarkers to aid in assessing risk factors and drug targets in a clinical setting.
My breast cancer research focuses on gene expression (RNA and microRNA) differences between breast cancer disease states. The overall goal is the identification of gene expression signatures that can identify the different breast cancer disease states at the molecular level to be used as a clinical tool for assessing patient prognosis and therapeutic treatments that will aid in the overall survival of the patient.
Publications
Croft D., Jordan R., Shriver C., Ellsworth D., “Performance of whole-genome amplified DNA isolated from serum on high density single nucleotide polymorphism arrays.” Manuscript Accepted to the Journal of Molecular Diagnostics(1/04/2008) - #JM07-0155
Russ M., Croft D., Ali O., Martinez R., Steimle PA., “Myosin heavy chain kinase A from Dictyostelium possesses a novel actin binding domain that cross-links actin filaments.” Biochem J. 2005, December 22.
Egelhoff, T.T., Croft, D.T., Steimle, P.A. “Actin-Activation of Myosin Heavy Chain Kinase A in Dictyostelium: A biochemical mechanism for the spatial regulation of myosin II filament disassembly.” JBC. 2004, November 14.
Conference Presentations
2011 Association of Molecular Pathology, Grapvine, TX
Daniel T. Croft, Jr., Laura Voeghtly, Heather L. Patney, Craig D Shriver, Marina N. Vernalis, and Darrell L. Ellsworth
“Performance of Whole-Genome Amplified DNA Isolated from Serum and Plasma for Estimating Copy Number Variation with High Density Single Nucleotide Polymorphism Arrays”
2011 Association of Molecular Pathology, Grapvine, TX
Laura M. Voeghtly, Daniel T. Croft, Jr., Brenda Deyarmin, Marina N. Vernalis, Craig D Shriver, and Darrell L. Ellsworth
“Utility of Whole Genome Amplification for Assessing Copy Number Variation with High Density SNP Arrays from Formalin-Fixed Paraffin Embedded Tissue”
2011 San Antonio Breast Care Symposium, San Antonio, TX
Ellsworth DL, Croft DT, Jr, Field LA, Deyarmin B, Kane J, Ellsworth RE, Hooke JA, Shriver CD. Windber Research Institute, Windber, PA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, MD; Walter Reed Army Medical Center, Washington, DC.
“Congruence between patterns of microRNA expression and histologic grading of invasive breast carcinomas”
2011 San Antonio Breast Care Symposium, San Antonio, TX
Rachel Ellsworth, Dan Croft, Darrell Ellsworth, Craig Shriver
“Effect of obesity on gene expression in invasive breast tumors”
2010 San Antonio Breast Care Symposium, San Antonio, TX
Jasmine Saini, Xing Li, Leonid Kvecher, Caroline Larson, Daniel Croft, Yaw-Ching Yang, Jeffrey A. Hooke, Craig D. Shriver, Richard J. Mural, and Hai Hu
“Differential Gene Expression Analysis among Post-menopausal Caucasian Invasive Breast Cancer, Benign and Normal Subjects”
2006 International Dictyostelium Conference, Santa Fe, New Mexico
D. Croft, Misty Russ, Omar Ali, Raquel Martinez, Paul Steimle
“Myosin heavy-chain kinase A from Dictyostelium possesses a novel actin-binding domain that cross-links actin filaments.”
2004 44th Annual Meeting of the American Society of Cell Biology, Washington DC
D. Croft, P. Brake, R. Martinez, M. Sharp, P. Steimle
“Studies of the Actin-Binding and Cellular Localization Activities of Myosin Heavy Chain Kinase A from Dictyostelium Reveal a Coiled-Coil Domain with Multiple Functions.”
2003 43rd Annual Meeting of the American Society of Cell Biology, San Francisco, CA
Daniel Croft, Kathy LaPoint, Thomas Egelhoff, Paul Steimle
“Dictyostelium Myosin Heavy Chain Kinase A is Activated by a Direct Interaction with Actin Filaments.”
2002 42nd Annual Meeting of the American Society of Cell Biology, San Francisco, CA
Daniel Croft, Leidy Tibaquira, Thomas Egelhoff, Paul Steimle
“Dictyostelium myosin heavy chain kinase A localizes to the actin-rich cortical structures via F-actin binding by its coiled-coil domain.”
