Office: Weyandt 319
E-mail: Katalin.Komjati@iup.edu
Telephone: 724-357-3323
Office Hours
Education
M.D. - Semmelweis University Medical School, Budapest, Hungary
Ph.D. (medical physiology) - Hungarian Academy of Sciences, Budapest, Hungary
Graduate and Postgraduate Instructional Trips
HUMSIRC - Aachen Medical University, Cardiology - Germany (graduate trip)
Postdoctoral Research Associate - University of Pennsylvania, Cerebrovascular Research Center, Philadelphia, USA (postgraduate trip)
Post Graduate Training and Fellowship Appointments
Ph.D. Fellowship - Hungarian Academy of Science at Semmelweis University of Medicine, Experimental Research Department and Second Institute of Physiology
NATO/Royal Society Fellowship - Wellcome Surgical Institute and Hugh Fraser Neuroscience Lab, University of Glasgow
NATO Fellowship - Inotek Corporation, Beverly Massachusetts, USA
Field
Human physiology
Interests
Human diseases, treatment, and therapy
Publications
Sandor P., Komjati K., Reivich M., Nyary I. (1994) Major role of nitric oxide in the mediation of regional CO2-responsiveness of the cerebral and spinal cord vessels of the cat. J. Cereb. Blood Flow Metab. 14 : 49-58
Komjati, K., Velkei-Harvich, M., Toth, J., Dallos, G., Nyary, I. and Sandor, P. (1996) Endogenous opioid mechanisms in hypothalamic blood flow autoregulation during hemorrhagic hypotension and angiotensin-induced acute hypertension in cats. Acta Physiol. Scand. 157: 53-61
K. Komjati, P. Sandor, M. Reivich, J.H. Greenberg, A.G.B. Kovach, J.L. Jaggi, I. Nyary (1996) Regional heterogeneity and differential vulnerability of cerebral and spinal vascular CO2-responsiveness during graded hemorrhagic hypotension. Acta Physiologica Hungarica 84:229-249
K. Komjati, P. Sandor, N. Sandor, L. Szirmai, M. H-Velkei, A.G.B. Kovach (1997) Cerebrocortical and medullary blood flow changes after general opiate receptor blockade during hemorrhagic shock in cats. Shock 7:288-293
K. Komjati, G. Dallos, M. H-Velkei and P. Sandor (1997) Central opiate receptor blockade by naloxone impairs thalamic and hypothalamic autoregulation in the cat. Pflügers Arch. Eur. J. Physiol. 434:144-146
K. Komjati, J. H. Greenberg, M. Reivich, P. Sandor (2001) Interactions between the EDRF/NO system and the endogenous opiate system in the modulation of cerebral and spinal vascular CO2-responsiveness. J. Cereb. Blood Flow Metab. 21:937-944
K. Kövecs, K. Komjati, T. Marton, J. Skopál, P. Sandor, Z. Nagy (2001) Hypercapnia stimulates prostagalandin E2 but not I2 release in endothelial cells cultured from microvessels of human fetal brain. Brain Res. Bull. 54:387-390
P. Pacher, J.G. Mabley, F.G. Soriano, L Liaudet, K Komjati and Cs. Szabó (2002) Endothelial dysfunction in aging animals: the role of poly-(ADP-ribose) polymerase activation. Brit. J. Pharmacol. 135:1347-1350
P. Pacher, L.Liaudet, J.G. Mabley, K. Komjati, Cs. Szabó (2002) Pharmacological inhibition of poly (ADP-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure. J. Am. Coll. Cardiol. 40:1006-1016
C. Szabo, A. Zanchi, K. Komjati, P.Pacher, A.S. Krolewski, W.C. Quist, F.W. LoGerfo, E.S.Horton, A. Veves (2002) Poly(ADP-Ribose) Polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivity. Circulation 106:2680-2686
B. Erdos, Z Lacza, I. E. Toth, E. Szelke, T. Mersich, K. Komjati, M. Palkovits, P. Sandor (2003) Mechanisms of pain-induced local cerebral blood flow changes in rat sensory cortex and thalamus. Brain Res. 960:219-227
P. Sandor, M. Reivich, K. Komjati (2003) Significance of endogenous opioids in the maintenance of cerebral and spinal vascular CO2-sensitivity in deep hemorrhagic hypotension. Brain Res. Bull. Vol 59:433-438
K. Shimoda, K. Murakami, P. Enkhbaatar, L.D. Traber, R.A. Cox, H.K. Hawkins, F.C. Schmalstieg, K. Komjati, J.G. Mabley, C. Szabo, A.L. Salzman and D. Traber (2003) Effect of poly(ADPribose) synthase inhibition on burn and smoke inhalation injury in sheep. Am. J. Physiol. Lung Cell Mol. Physiol. 285:L240-L249
Minchenko AG, Stevens MJ, White L, Abatan OI, Komjati K, Pacher P, Szabo C, Obrosova IG. (2003) Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation. FASEB J. 17:1514-6
Lacza Z, Horvath EM, Komjati K, Hortobagyi T, Szabo C, Busija DW(2003 ) PARP inhibition improves the effectiveness of neural stem cell transplantation in experimental brain trauma. Int. J. Mol. Med. 12:153-9
Lohinai Z, Mabley JG, Feher E, Marton A, Komjati K, Szabo C. (2003) Role of the activation of the nuclear enzyme poly(ADP-ribose) polymerase in the pathogenesis of periodontitis. J. Dent. Res. 82:987-92
Khan TA, Ruel M, Bianchi C, Voisine P, Komjati K, Szabo C, Sellke FW. (2003) Poly(ADP J ribose) polymerase inhibition improves postischemic myocardial function after cardioplegia-cardiopulmonary bypass. Am. Coll. Surg. 197:270-7
Obrosova IG, Li F, Abatan OI, Forsell MA, Komjati K, Pacher P, Szabo C, Stevens MJ. (2004) Role of poly(ADP-ribose) polymerase activation in diabetic neuropathy. Diabetes. 53:711-20
Komjati K, Mabley JG, Virag L, Southan GJ, Salzman AL, Szabo C. (2004) Poly(ADP-ribose) polymerase inhibition protect neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke. Int. J. Mol. Med. 13:373-82
Murakami K, Enkhbaatar P, Shimoda K, Cox RA, Burke AS, Hawkins HK, Traber LD, Schmalstieg FC, Salzman AL, Mabley JG, Komjati K, Pacher P, Zsengeller Z, Szabo C, Traber DL. (2004) Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis. Shock. 21:126-33
Szabo C, Pacher P, Zsengeller Z, Vaslin A, Komjati K, Benko R, Chen M, Mabley JG, Kollai M. (2004) Angiotensin II-mediated endothelial dysfunction: role of poly(ADP-ribose) polymerase activation. Mol Med. 2004 10:28-35
Komjati K, Besson VC, Szabo C. (2005) Poly (ADP-ribose) polymerase inhibitors as potential therapeutic agents in stroke and neurotrauma. Curr. Drug Targets CNS Neurol. Disord. 4:179-94
Szelke E, Varbiro S, Mersich T, Banhidy F, Szekacs B, Sandor P, Komjati K. (2005) Effects of J estrogen and progestin on hypothalamic blood flow autoregulation. Soc. Gynecol. Investig. 12:604-9
Krizbai IA, Lenzser G, Szatmari E, Farkas AE, Wilhelm I, Fekete Z, Erdos B, Bauer H, Bauer HC, Sandor P, Komjati K. (2005) Blood-brain barrier changes during compensated and decompensated hemorrhagic shock. Shock. 24:428-33
Lenzser G, Kis B, Snipes JA, Gaspar T, Sandor P, Komjati K, Szabo C, Busija DW. (2007) Contribution of poly(ADP-ribose) polymerase to postischemic blood-brain barrier damage in rats. J. Cereb. Blood Flow Metab. 2007 Jan 10
Mersich T, Szelke E, Erdos B, Lacza Z, Komjati K, Sandor P. (2007) Somatosensory pain does not affect total cerebral blood volume. Neuroreport. 18:649-52
Szelke E, Mersich T, Szekacs B, Sandor P, Komjati K, Varbiro S. (2008) Effects of estrogen and progestin on the CO2 sensitivity of hemispheric blood volume. Menopause 15:346-51
Bela Horvath, Gabor Lenzser, Balazs Benyo, Tamas Nemeth, Rita Benko, Andras Iring, Peter Herman, Katalin Komjati, Zsombor Lacza, Peter Sandor, Zoltan Benyo (2010) Hypersensitivity to tromboxane receptor mediated cerebral vasomotion and CBF oscillations during acute NO- deficiency in rats. PLOS-online, 5:1-6
