Office: Weyandt 125
E-mail: CDiep@iup.edu
Telephone: 724-357-2269
Office Hours
Visit Dr. Diep’s homepage.
Education
B.S. - Messiah College
Ph.D. - Pennsylvania State University, College of Medicine
Visiting Research Associate - University of Pittsburgh
Postdoctoral Fellowship - Harvard Medical School/Massachusetts General Hospital
Field
Stem Cell and Regenerative Medicine, Developmental Biology, Kidney
Interests
I am interested in understanding kidney regeneration and kidney development using zebrafish as a vertebrate model system. Kidney disease is a major health problem worldwide due to increasing rates of diabetes and hypertension, and current treatments (such as dialysis and kidney transplant) are not meeting the demand of patients. As such, there is an urgent need for an alternative stem cell/regenerative therapy for treating kidney disease. To this end, I have recently identified for the first time stem cells that are capable of regenerating new kidney tissue in adult zebrafish (Diep et al., Nature, 2011). Projects in my lab focus on how these stem cells are regulated during regeneration and determining their role in development of the adult kidney. Understanding the mechanism that controls these stem cells in zebrafish will provide a first step towards developing a novel stem cell/regenerative therapy for treating kidney disease.
Publications
Diep C.Q., Ma D., Deo R.C., Holm T.M., Naylor R.W., Arora N, Wingert R.A., Bollig F., Djordjevic G., Lichman B., Zhu H., Ikenaga T., Ono F., Englert C., Cowan C.A., Hukriede N.A., Handin R.I., and Davidson A.J. (2011) Identification of adult nephron progenitors capable of kidney regeneration in zebrafish. Nature 470: 95-100
Swanhart L.M., Cosentino C.C., Diep C.Q., Davidson A.J., de Caestecker M., and Hukriede N.A. (2011) Zebrafish kidney development: Basic science to translational research. Birth Defects Research (Part C: Embryology Today: Reviews) 93: 141-56
Diep C.Q. and Davidson A.J. (2011) Transplantation of cells directly into the kidney of adult zebrafish. Journal of Visualized Experiments 51
Diep C.Q., Tao X., Pilauri V., Losiewicz M., Blank T.E., and Hopper J.E. (2008) Genetic evidence for sites of interaction between the Gal3 and Gal80 proteins of the Saccharomyces cerevisiae GAL gene switch. Genetics 178: 725-36.
Diep C.Q., Peng G., Bewley M., Pilauri V., Ropson I, and Hopper J.E. (2006) Intragenic suppression of Gal3C interaction with Gal80 in the Saccharomyces cerevisiae GAL gene switch. Genetics 172: 77-87
Pilauri V., Bewley M., Diep C., and Hopper J.E. (2005) Gal80 dimerization and the yeast GAL gene switch. Genetics 169: 1903-14
