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Lee to Present on the Structure and Assembly of Nucleosomes

Dr. Tae-Hee Lee, an assistant chemistry professor from Penn State Unversity, will visit the Department of Chemistry on Friday, October 28, 2011, to visit with faculty and present on his research.

Dr. Lee is interested in using spectroscopy and microscopy to investigate single molecule biophysics. His talk, “Single Molecule Studies on the Structure and Assembly of Nucleosomes,” will be given in Weyandt 240 from 3:35 to 4:25 p.m. Light refreshments will be served, and all are welcome to attend.

Abstract

Nucleosomes are the fundamental packing units of the eukaryotic genome. The structure and structural dynamics of nucleosomes are at the core of the mechanisms of gene regulation. We studied the structure of nucleosomes, the assembly of nucleosomes, and how these properties are altered by covalent modifications based on single molecule fluorescence measurements. Our study revealed that changes in the physical properties of nucleosomes induced upon DNA methylation and histone acetylation may contribute to the regulation of various genome activities. Our study demonstrates how single molecule methods can fill the niche not covered by the conventional structural biology tools.

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