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April Meeting of Behavioral Neuroscience Journal Club

Posted on 4/18/2017 10:18:36 AM

The April 2017 meeting of the Behavioral Neuroscience Journal Club will be on Friday, April 21, in 118 Uhler Hall. All are welcome to attend.  Dan Widzowski (Biology) will describe research seeking new treatments for methamphetamine addiction.

Abstract:

No currently approved medicine to treat methamphetamine dependence (MAD) exists, although the atypical antidepressant mirtazapine has shown promise in both animal and human tests for MAD.

The biochemical mechanisms of mirtazapine in MAD are poorly understood, and it has many side effects. Thus, new, improved drugs derived from mirtazapine may have significant potential in MAD.

We are conducting pilot studies in chemistry, biology, and psychology to support a research collaboration with Duquesne University that seeks to identify novel compounds that have potential to treat MAD and test them for desired activity in biochemical assays and animal behavioral models.

To further this project, we need to conduct preliminary studies to test mirtazapine and prototype (tool) compounds that may have some of the desired properties for treating MAD to validate our test systems and learn how the prototype/tool compounds could be improved.

College of Natural Sciences and Mathematics