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Horne to Present on Biomolecular Connectivity

Posted on 11/1/2011 5:28:27 PM

Dr. W. Seth Horne, University of Pittsburgh, will visit the Department of Chemistry on Friday, November 4, 2011, to visit with faculty and students before presenting a research talk.

At 3:35 p.m., in Weyandt 240, he will present the lecture “Proteins as Play-Doh: Changing the Chemical Connectivity of Biomolecules to Make New Materials and Medicines.” All are welcome to attend, and light refreshments will be served.


Research in the Horne lab at the University of Pittsburgh is focused on the design, synthesis, and study of synthetic analogues of polypeptides and proteins. The cellular machinery underlying life is based on biopolymers comprised of a handful of simple building blocks. Application of synthetic organic chemistry to the modification of proteins provides an avenue to chemical species that are inspired by nature, but manifest new and interesting properties. Projects being pursued in the lab include the development of new chemical methods to control folded conformation in polypeptides and proteins, exploration of the consequences of chemical modification to the folding of the polypeptide backbone, and the application of protein self-assembly to prepare functional supramolecular materials.